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KMID : 1100220110100030102
Dementia and Neurocognitive Disorders
2011 Volume.10 No. 3 p.102 ~ p.105
A Case of Nonvasculitic Autoimmune Inflammatory Meningoencephalitis Accompanied by Sjogren¡¯s Syndrome and Elevated Antithyroid Antibodies
Lee Seong-Joon

Sohn Sung-Yun
Lim Tae-Sung
Moon So-Young
Abstract
Background: Nonvasculitic autoimmune inflammatory meningoencephalitis (NAIM) is known to be one of the causes of potentially reversible dementia. NAIM can be accompanied by various autoimmune diseases.

Methods: A 65 year-old woman had been treated with stable bipolar disorder and presented with rapid cognitive decline, visual hallucination and myoclonus. Anti-thyroid antibodies were elevated. Her symptoms were responsive to steroid therapy. Her diagnostic evaluation also revealed Sjogren¡¯s syndrome. Although her symptoms recovered, a manic episode reappeared and was responsive to psychiatric treatment.

Conclusions: Patients presenting with rapidly progressive dementia should be thoroughly evaluated for the diagnosis of NAIM, a potentially treatable form of dementia, and the possible various underlying autoimmune etiologies.
KEYWORD
Nonvasculitic autoimmune inflammatory meningoencephalitis, Sjogren¡¯s syndrome, Steroid responsive encephalopathy associated with autoimmune thyroiditis, Bipolar disorder
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